The role of NL-Epithalon in maintaining healthy, supple, and firm skin on the face and body.

Restores the skin to its normal condition, improving its elasticity, suppleness, and hydration. Peptide therapy against skin imperfections, including cellulite and wrinkles. 

Abstarct: The use of Epithalon for skin care has a strong basis in contemporary scientific research. Once Epithalon enters the body, processes begin that enable the skin to remain healthy, supple, and firm. Thanks to its action, the number of fibroblasts increases, which stimulates the production of more collagen. As a result, the skin becomes firmer and more elastic, and therefore less prone to wrinkles, especially in sensitive areas such as the lips and eyes. Keywords: epithalon; circadian rhythm; sleep; sleep quality; melatonin; balance; insomnia; sleep phases; metabolism; synthesis; release; sleep disorders; melatonin receptors; telomere shortening; stimulation List of abbreviations: SCN- SPZ- NREM; ALA; ASP; GLU 

Introduction

Studies conducted on the effectiveness of NL-Epithalon have shown that this peptide can activate skin fibroblasts, the cells responsible for repairing and maintaining the extracellular matrix that keeps our skin firm, elastic, and strong. The extracellular matrix of the skin is where collagen, elastin, and other critical skin proteins are found.

SKIN STRUCTURE

As we know, our skin has a very complex structure and, as the surface covering our body, it is one of the largest organs in our body. The condition of our skin often reflects the condition of our entire body. The skin consists of two main layers: the outer and inner layers. The first, visible, hairy outer layer is the epidermis, which forms a barrier between the external environment and the internal environment of the body. The second, invisible, hairless layer is called the dermis, which contains important nerve endings, hair follicles, and sweat and sebaceous glands. The subcutaneous layer, which is closely related to the skin, is not considered part of it. It consists mainly of adipose tissue, with only a small percentage of connective tissue. The subcutaneous tissue structures contain nerve fibers and blood vessels. The main function of the subcutaneous layer is its participation in the process of thermoregulation, which is of great importance for the entire body.

SKIN FUNCTIONS

Human skin performs many physiological functions. It plays an important physiological role, protecting internal organs from harmful environmental, physical, chemical, and microbiological factors. It also helps maintain balance between the body and its surroundings. The most important and widely known functions of the skin include the aforementioned protective function, as well as the body's thermoregulatory function, participation in water and secretion management, participation in the synthesis of proteins and certain compounds, and participation in the metabolism of proteins, lipids, and carbohydrates. In addition, it plays an important role in the body's immune response and sensory stimulation. Healthy skin is free from damage caused by improper care or adverse environmental influences, tolerates changes in temperature and humidity well, and responds correctly to most tested and approved skincare products. 

DERMIS

In this article, we will focus on cells found in the dermis, such as fibroblasts, histiocytes, and fibrocytes. This layer also contains three types of fibers: reticular, elastic, and collagen fibers, which are responsible for the proper elasticity and tension of the skin. The weakening of these fibers is the direct cause of the loss of the desired appearance of the skin. With age, both the quantity and quality of these fibers decrease, the skin becomes thin and flaccid, and wrinkles form on its surface. The levels of collagen, elastin, and fibrin decrease not only with age (this process begins around the age of 30) but also under the influence of factors related to an unhealthy lifestyle, including poor nutrition, in which the diet is deficient in essential vitamins, minerals, and fatty acids, as well as exposure of the skin to the sun, alcohol consumption, smoking, stress, lack of physical activity, and taking certain medications.

COLLAGEN FIBERS OF THE SKIN

Collagen is the main structural protein of the skin, accounting for approximately 72% of its dry weight. It is produced by fibroblasts in the dermis. It takes the form of a triple helix and consists of three chains containing approximately one hundred amino acids. Together with elastin, it gives the skin tension, elasticity, firmness, resilience, resistance to damage, and stretchability. The skin is primarily built up of type I collagen, known as the collagen of youth (the dermis contains approximately 80% type I collagen and 20% type III collagen).

As mentioned above, collagen fibers weaken with age and an unhealthy lifestyle. In addition, new fibers are of increasingly poor quality, becoming shorter, more twisted, and weaker, and their degradation is influenced by external factors such as pollution and UV rays.

ELASTIC AND RETICULAR FIBERS

Reticular fibers are scattered between collagen fibers. They are found in greater quantities in skin papillae, and their chemical structure and origin have not yet been fully researched. Elastic fibers intertwine with collagen fibers, giving the skin its elasticity and stretchiness. As the skin ages (due to age or an unhealthy lifestyle), the elastic fibers degenerate and clump together with the collagen fibers into an amorphous mass, leading to a decrease in collagen synthesis and impaired angiogenesis (the formation of new blood vessels). The consequences of these changes in connective tissue are the formation of wrinkles and furrows, reduced elasticity and firmness, and increased skin sensitivity.

CHARACTERISTICS OF THE PENETRATION OF THE NL-EPITHALON PEPTIDE IN THE CAPSULE

The previous problem associated with the breakdown of the NL-Epithalon peptide in the body has been solved by changing its chemical form, whereby the basic form of the NL-Epithalon peptide is modified and transformed into a highly stable form. The basic form of NL-Epithalon, during modification, through coupling with additional amino acids, allows for increased stability of the peptide and overcoming the existing stomach barrier. When comparing the tablet form of the preparation with the topical skin preparation, it is worth noting that in the case of the oral medication, the active substance acts systemically, passing through the digestive tract, penetrating the patient's bloodstream, and being excreted by the kidneys. The use of the peptide in capsule form leads to an enhanced therapeutic effect, in a shorter period of time and with greater efficacy. In addition, in the case of severe symptoms, the cosmetic preparation may be insufficient. The optimal and most beneficial effects can be observed when both preparations are used in combination.

NL-EPITALON'S ABILITY TO PRODUCE COLLAGEN

Our body constantly maintains a certain level of collagen production, but it does not cover naturally occurring losses. However, the body has the ability to increase collagen production if it receives the right signal. With the onset of the aging process, 2% of collagen in the skin is lost each year. When collagen fibers loosen and float around the body, they are too small to initiate a sufficient production process. However, if the amount of floating collagen suddenly increases, the body will increase production to replenish its reserves. Thanks to its ability to stimulate the synthesis of type I and III collagen, NL-Epithalon smooths, tightens, and brightens the skin, which is visible after only a short period of use, providing the expected results not only for mature individuals but also for those who struggle with dehydrated, rough, and tired skin that lacks radiance.

 NL-EPITALON PROPERTIES ELIMINATE WRINKLES, SKIN AGING, IMPROVING FIRMNESS, ELASTICITY AND RADIANCE FOR MATURE, TIRED OR DEHYDRATED SKIN

Not only with the passing of years, but also with an unhealthy lifestyle and skin in need of hydration and tone improvement, we develop skin problems such as wrinkles, which are the result of changes in the dermis. There is a decrease in collagen production. At the same time, the ability of cells to regenerate gradually decreases. Capillaries, which supply blood cells with important nutrients, become less efficient. In order to restore balance with reduced biological activity, our skin gets rid of moisture-binding cells. This, in turn, leads to dry skin. NL-Epithalon, enclosed in a capsule, stimulates the growth and development of fibroblasts, which secrete proteins such as collagen, thanks to its ability to penetrate cells. This improves skin quality and regenerates it in multiple stages at all possible levels. The extracellular matrix of the skin is where collagen, elastin, and other critical skin proteins are found. Studies on the NL-Epithalon peptide have shown that by activating fibroblasts by as much as half, repair and maintenance of the extracellular matrix, which significantly improves the condition of the skin and prevents the formation of new skin lesions.

PROPERTIES OF NL-EPITALON THAT ELIMINATE CELLULITE

Most women over the age of 25 suffer from cellulite, a skin imperfection. Estimates show that this affects around 90% of women, including, contrary to popular belief, those who exercise and lead a healthy lifestyle. Cellulite is caused by hormonal imbalances in the body, which result in uneven distribution of fat tissue. Cellulite most often occurs in the buttocks, abdomen, hips, and forearms, i.e., the areas that store the most fat. Cellulite can therefore be divided into the following main types:

1. Water cellulite, which mainly affects slim people and is caused by impaired blood and lymph circulation in the tissues;
2. Fat cellulite, which mainly affects overweight people and causes changes in the deeper layers of the skin and connective tissue. Visible dimples and lumps appear on the skin.

The elimination of cellulite should begin with lifestyle changes, appropriate exercise, supportive cosmetics, treatments, and, importantly, appropriate supplementation. Experience has shown that NL-Epithalon, which does not cause side effects or adverse allergic reactions, supports collagen synthesis, reduces cellulite, moisturizes the skin, firms it, and increases skin tension.

EPITALON'S PROPERTIES ELIMINATE DIABETIC ULCERS

Research has shown that preventing skin aging is more than just improving appearance. Aging skin is brittle, prone to tearing, and often susceptible to chronic injuries that lead to bedsores, diabetic ulcers, and other damage. The ability to rejuvenate the skin will not only improve its appearance; in fact, it will prevent damage, disease, infection, and more. An additional and important spectrum of NL-Epithalon's action is its ability to heal wounds that arise as a result of diabetes. Skin ulcers and burning sensations are caused by diabetes. The results of the study indicate that wound healing in diabetic foot ulcers is a complex and extremely demanding biological and molecular process that involves the coordinated actions of many types of cells. The search for a solution to the problem of preventing and eliminating such skin changes has been unsuccessful. Studies on the NL-Epithalon peptide clearly indicate that it has properties that allow it to prevent and repair skin after changes caused by the disease have already occurred. The spectrum of action of NL-Epithalon is based on its positive effect during the three stages of wound healing, including the induction of macrophage recruitment to the wound site during the inflammatory response, the promotion of migration and proliferation of both keratinocytes and fibroblasts, leading to re-epithelialization and granulation tissue formation. The spectrum of action of NL-Epithalon is based on its positive effect during three stages of wound healing, including the induction of macrophage recruitment to the wound site during the inflammatory response stage, promoting the migration and proliferation of both keratinocytes and fibroblasts, leading to re-epithelialization and granulation tissue formation, and the tissue remodeling phase, by promoting the release of transforming TGF-β1 and interleukin 6 (IL-6) and activating mitogen-activated protein kinase (MAPK) signaling pathways. 

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