English
EPITHALON EXERTS REGENERATIVE AND ANTI-AGING EFFECTS THROUGH:
- Telomerase activation — extends telomeres within cells, protecting DNA from degradation and supporting cellular longevity.
- Gene expression regulation — modulates the activity of genes linked to DNA repair, metabolism, and inflammatory balance.
- Normalization of circadian rhythm — stabilizes melatonin secretion, improving sleep quality and nighttime recovery.
- Antioxidant activity — reduces oxidative stress, neutralizes free radicals, and protects mitochondrial function.
- Support of cellular immunity — enhances tissue regeneration, particularly within the nervous and endocrine systems.
💡 Effect: Slower cellular aging, deeper sleep, stronger immunity, and a measurable improvement in vitality and recovery.
PEPTIDE STRUCTURE — EPITHALON
- Amino acid sequence: Ala-Glu-Asp-Gly
- Molecular formula: C₁₄H₂₂N₄O₉
- Molecular weight: 390.35 g/mol
- Form: Lyophilized powder (white, hygroscopic), readily soluble in water
RESEARCH & BIOLOGICAL ACTIVITY
Epithalon and Telomere Dynamics
Studies by Prof. Khavinson demonstrated that Epithalon activates telomerase, the enzyme responsible for rebuilding chromosomal ends (telomeres).
Extended telomeres translate into slower cellular aging and improved regenerative capacity.
Epithalon, the Nervous System, and Sleep Regulation
Epithalon helps restore circadian balance by stimulating the natural production of melatonin.
It improves sleep quality, mental focus, and stress resilience. Clinical trials report reduced fatigue and enhanced cognitive performance in older adults.
Epithalon and Regeneration / Immunity
The peptide strengthens immune activity and promotes the regeneration of bone marrow and neural tissue.
It acts as an immunomodulator, helping maintain a healthy balance between inflammatory and regenerative processes.
Epithalon, Oxidative Stress, and Aging
Epithalon neutralizes free radicals and protects DNA from oxidative damage.
In animal studies, it has been shown to extend average lifespan by 25–30%, while improving physical endurance and stress resistance.
| Property | Biological Effect |
|---|---|
| Telomerase activation | Slows cellular aging and supports longevity |
| Regulation of circadian rhythm | Improves sleep quality and nightly recovery |
| Antioxidant activity | Protects DNA and mitochondrial integrity |
| Immune support | Enhances cellular regeneration and immune resilience |
| Neuroprotective action | Improves mood, focus, and cognitive function |
Bibliography
- V.Kh Khavinson, Peptides and Ageing. 2002; 3:11-144
- V.Khavinson, M.Razumovsky, S.Trofimova, R.Grigorian, A.Razumovskaya, Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa, 2002; 365-8
- Apostolopoulos V, Bojarska J, Chai TT, et al. A Global Review on Short Peptides: 2.Frontiers and Perspectives. Molecules. 2021;26(2):430. Published 2021 Jan 15. doi:10.3390/molecules26020430
- Adult Treatment Panel III.: Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel of detection, evaluation and treatment of high blood cholesterol in adults. JAMA 2001, 285: 2486-97
- D.Sibarov, R.Kovalenko, V.Malinin, V.Khavinson, Epitalon influences pineal secretion in stress-exposed rats in the daytime. 2002; 23(5-6):452-4
- L.Kozina, Investigation of antihypoxic properties of short peptides. 2008;21(1):61-7
- V.Khavinson, E.Korneva, V.Malinin, E.Rybakina, I.Ivanovich, S,Shanin, Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress. 2002; 23(5-6):411-6
- X.Yue, S. Liu, J. Guo, T. Meng, X. Zhang, H. Li, C. Song, Z. Wang, H. Schatten, Epitalon protects against postovulatory aging-related damage of mouse oocytes in vitro. 2022 Apr 15; 14(7): 3191–3202. 10.18632/aging.204007