English
SEMAX SHOWS NEUROREGENERATIVE AND MIND-ENHANCING EFFECTS THANKS TO:
- Stimulation of BDNF and NGF – increases the activity of nerve growth factors, supporting nerve flexibility and neuron regeneration.
- Strengthening cognitive functions – improves working memory, focus, and learning ability.
- Neuroprotective action – protects nerve cells against oxidative stress, lack of oxygen, and toxins.
- Regulation of the stress axis (HPA) – stabilizes cortisol levels and improves the body's resistance to mental and physical stress.
- Increasing energy metabolism in the brain – supports the use of oxygen and glucose in neurons.
💡 Effect: better concentration, faster information processing, greater mental resilience, and nervous system regeneration after effort or stress.
STRUCTURE OF THE SEMAX PEPTIDE
- Amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular formula: C₃₇H₅₁N₉O₁₀S
- Molecular weight: 869.93 g/mol
- Form: white freeze-dried powder, water-soluble, thermally stable
RESEARCH AND BIOLOGICAL ACTION
SEMAX and the nervous system and memory
Studies have shown that SEMAX increases the expression of BDNF and its receptors (TrkB), which directly supports nerve flexibility and the formation of new synaptic connections. In animal and clinical models, improvements in memory, focus, and information processing speed were observed.
SEMAX and stress and emotional balance
SEMAX affects the hypothalamus–pituitary–adrenal (HPA) axis, normalizing cortisol levels. It acts against stress, improving mental resilience and emotional stability. Clinical studies also showed relief of fatigue symptoms and increased motivation.
Figure 1. The study showed the liver of the subject after exposure to strong stress. Images a and b come from observations immediately after subjecting the individual to stress and show liver tissue damaged by stress. Images c and d come from observations after administering the Semax peptide and show a reduction in stress-induced damage. The study thus proves the positive effect of the Semax peptide in reducing the effects of stressful situations and lowering the body's stress itself.
SEMAX and neuroprotection and regeneration
The peptide shows strong antioxidant and anti-hypoxia effects, protecting neurons from oxygen deficiency and oxidative damage. It supports regeneration after brain and spinal cord injuries, improving microcirculation and neuron metabolism.
SEMAX and the circulatory system and oxygenation
SEMAX supports the function of the blood vessel lining, improves brain blood flow, and oxygen delivery to neurons. This reduces the risk of micro-injuries and improves the body's oxygen capacity.
| Property | Biological effect |
|---|---|
| Increase in BDNF and NGF expression | Regeneration and nerve flexibility |
| Improvement of cognitive functions | Better memory and focus |
| Neuroprotective action | Protection of nerve cells |
| Cortisol regulation | Greater resistance to stress |
| Support of microcirculation | Better oxygenation and mental performance |
Bibliography
- A.Ivanov, I.Bobyntsev, O.Shepeleva, A.Kryukov, L.Andreeva, N.Myasoedov, Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress. 2017; 163;1. DOI 10.1007/s10517-017-3748-4
- O.Dołotow, E. Karpenko, L. Inozemcewa, T. Seredenina, N. Lewicka, J. Rozyczki, E.Dubynina, E,Novosadova, Semax, ACTH(4-10) analog with cognitive action, regulates expression of BDNF and trkB in rat hippocampus. 2006; 1117(1):54-60. doi: 10.1016/j.brainres.2006.07.108