English
EPITHALON EXHIBITS REGENERATIVE AND ANTI-AGING EFFECTS THANKS TO:
- Activation of telomerase – lengthens telomeres in cells, protecting DNA from degradation and supporting their viability.
- Regulation of gene expression – modulates the activity of genes related to DNA repair, metabolism, and inflammatory processes.
- Normalization of circadian rhythm – stabilizes melatonin secretion, improving sleep quality and nighttime regeneration.
- Antioxidant action – reduces oxidative stress, neutralizes free radicals, and protects mitochondria.
- Supporting cellular immunity – aids tissue regeneration, especially in the nervous and hormonal systems.
💡 Effect: slower cell aging, better sleep, increased resistance, and overall vitality improvement.
EPITHALON PEPTIDE STRUCTURE
- Amino acid sequence: Ala-Glu-Asp-Gly
- Empirical formula: C₁₄H₂₂N₄O₉
- Molecular weight: 390.35 g/mol
- Form: lyophilizate (white, hygroscopic), easily soluble in water
RESEARCH AND BIOLOGICAL ACTIVITY
Epithalon and telomeres and DNA
Prof. Khavinson’s research showed that Epithalon activates the enzyme telomerase, which rebuilds chromosome ends – telomeres.
Extended telomeres translate into slower cell aging and greater regenerative capacity.
Epithalon and the nervous system and sleep
Epithalon supports circadian rhythm balance, increasing natural melatonin production.
Improves sleep quality, concentration, and the ability to adapt to stress. Clinical studies have recorded a reduction in fatigue symptoms and improvement in cognitive functions in elderly people.
Epithalon and regeneration and immunity
The peptide enhances immune system activity, supports the regeneration of bone marrow cells and the nervous system.
It acts immunomodulatory, helping the body maintain a balance between inflammatory and regenerative responses.
Epithalon and oxidative stress and aging
Epithalon neutralizes free radicals and protects DNA from oxidative damage.
In animal model studies, it has been shown to extend the average lifespan by 25–30%, while simultaneously improving physical performance and stress resistance.
Figure 1. In this study conducted on animal oocytes, the effect of Epithalon on halting cell aging was observed. The image in the control group shows oocyte cells, the next image shows aging cells, and the image labeled “Epithalon” shows the halting of cell aging. The cells in the image, under the influence of the Epithalon peptide, are present in the same quantity, and all their damage has been minimized, demonstrating the anti-aging potential of the peptide.
| Property | Biological effect |
|---|---|
| Telomerase activation | Slowing down cell aging |
| Circadian rhythm regulation | Improvement of sleep quality and regeneration |
| Antioxidant action | DNA and mitochondria protection |
| Immune support | Better cellular regeneration and resistance |
| Neuroprotective effect | Mood and cognitive function improvement |
Bibliography
- V.Kh Khavinson, Peptides and Ageing. 2002; 3:11-144
- V.Khavinson, M.Razumovsky, S.Trofimova, R.Grigorian, A.Razumovskaya, Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa, 2002; 365-8
- Apostolopoulos V, Bojarska J, Chai TT, et al. A Global Review on Short Peptides: 2.Frontiers and Perspectives. Molecules. 2021;26(2):430. Published 2021 Jan 15. doi:10.3390/molecules26020430
- Adult Treatment Panel III.: Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel of detection, evaluation and treatment of high blood cholesterol in adults. JAMA 2001, 285: 2486-97
- D.Sibarov, R.Kovalenko, V.Malinin, V.Khavinson, Epitalon influences pineal secretion in stress-exposed rats in the daytime. 2002; 23(5-6):452-4
- L.Kozina, Investigation of antihypoxic properties of short peptides. 2008;21(1):61-7
- V.Khavinson, E.Korneva, V.Malinin, E.Rybakina, I.Ivanovich, S,Shanin, Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress. 2002; 23(5-6):411-6
- X.Yue, S. Liu, J. Guo, T. Meng, X. Zhang, H. Li, C. Song, Z. Wang, H. Schatten, Epitalon protects against postovulatory aging-related damage of mouse oocytes in vitro. 2022 Apr 15; 14(7): 3191–3202. 10.18632/aging.204007