SEMAX PROMOTES NEUROREGENERATION AND COGNITIVE PERFORMANCE THROUGH:
- Stimulation of BDNF and NGF — increases neurotrophic factor activity, enhancing neuroplasticity and neuronal repair.
- Enhanced cognitive function — improves working memory, focus, and learning capacity.
- Neuroprotective action — shields neural cells from oxidative stress, hypoxia, and toxins.
- Regulation of the stress axis (HPA) — stabilizes cortisol levels and strengthens resilience to psychological and physical stress.
- Improved brain energy metabolism — optimizes oxygen and glucose utilization in neurons.
💡 Effect: Sharper concentration, faster information processing, enhanced mental endurance, and accelerated neural recovery after stress or exertion.

PEPTIDE STRUCTURE — SEMAX
- Amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular formula: C₃₇H₅₁N₉O₁₀S
- Molecular weight: 869.93 g/mol
- Form: White lyophilized powder, water-soluble, thermally stable

RESEARCH & BIOLOGICAL ACTIVITY
SEMAX and the Nervous System / Memory
Studies show that SEMAX upregulates BDNF expression and its receptor TrkB, directly enhancing neuroplasticity and the formation of new synaptic connections.
In both animal and clinical models, SEMAX improved memory, concentration, and processing speed.
SEMAX, Stress, and Emotional Balance
SEMAX modulates the hypothalamic–pituitary–adrenal (HPA) axis, normalizing cortisol levels and improving stress resilience.
It exerts a calming yet energizing effect, reducing fatigue while enhancing motivation and emotional stability.
SEMAX, Neuroprotection, and Regeneration
The peptide exhibits strong antioxidant and anti-hypoxic activity, protecting neurons from oxidative damage and oxygen deprivation.
It supports neural repair after brain or spinal injuries, improving microcirculation and neuronal metabolism.
SEMAX and Circulation / Oxygenation
SEMAX promotes endothelial function and increases cerebral blood flow, enhancing oxygen delivery to neurons.
This translates into reduced microdamage risk and greater mental and physical endurance.
| Property | Biological Effect |
|---|---|
| Upregulation of BDNF and NGF | Neuronal regeneration and neuroplasticity |
| Enhanced cognitive function | Improved memory, focus, and learning |
| Neuroprotective activity | Cellular protection from oxidative damage |
| Cortisol regulation (HPA axis) | Greater resistance to stress |
| Improved microcirculation | Better oxygenation and mental performance |
Bibliography
- A.Ivanov, I.Bobyntsev, O.Shepeleva, A.Kryukov, L.Andreeva, N.Myasoedov, Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress. 2017; 163;1. DOI 10.1007/s10517-017-3748-4
- O.Dolotov, E. Karpenko, L. Inozemtseva, T. Seredenina, N. Levitskaya, J. Rozyczka, E.Dubynina, E.Novosadova, Semax, ACTH(4-10) analog with cognitive effects, regulates BDNF and TrkB expression in rat hippocampus. 2006; 1117(1):54-60. doi: 10.1016/j.brainres.2006.07.108




