SELANK EXERTS NEUROREGULATORY AND ANTI-STRESS EFFECTS THROUGH:
- Modulation of serotonergic and dopaminergic systems — restores emotional balance and reduces tension and anxiety.
- Upregulation of BDNF expression — supports neuroplasticity and neuronal regeneration.
- Influence on GABA activity — provides natural calming without sedation or cognitive dulling.
- Improved sleep and concentration — stabilizes circadian rhythm and promotes mental recovery.
- Immunomodulatory action — enhances immune response and reduces inflammation.
💡 Effect: A calm, focused mind, deeper sleep, and enhanced psychological resilience to everyday stress.

PEPTIDE STRUCTURE — SELANK
- Amino acid sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Molecular formula: C₃₃H₅₇N₁₁O₉
- Molecular weight: 751.89 g/mol
- Form: White lyophilized powder, water-soluble, and stable across a wide pH range

RESEARCH & BIOLOGICAL ACTIVITY
SELANK and the Nervous System / Mood Regulation
SELANK modulates dopaminergic and serotonergic activity, helping to stabilize mood and reduce hyperexcitability.
Clinical studies demonstrate that it alleviates anxiety and emotional tension while improving concentration and working memory.
SELANK and Sleep / Recovery
By influencing serotonin and melatonin synthesis, SELANK helps regulate the circadian rhythm.
It promotes faster sleep onset, deeper slow-wave sleep, and enhanced nighttime recovery — all without daytime drowsiness or dependence.
SELANK, Oxidative Stress, and Immunity
SELANK lowers levels of pro-inflammatory cytokines (notably IL-6), reducing oxidative stress and strengthening immune defense.
In vivo models confirm its anti-inflammatory and immunomodulatory effects — increasing resistance to infection and promoting overall homeostasis.
SELANK and Cognitive Performance
Through its action on neurotransmitters and neurotrophic factors, SELANK enhances memory, reaction speed, and mental clarity.
Clinical data show improved performance in cognitive tests and more efficient information processing under stress.
| Property | Biological Effect |
|---|---|
| Serotonin & dopamine modulation | Reduced stress and emotional tension |
| Increased BDNF expression | Neuronal regeneration and improved mood |
| Circadian rhythm regulation | Better sleep and focus |
| Influence on GABA | Natural calm without sedation |
| Immunomodulatory activity | Enhanced immune function and systemic balance |
Bibliography
- T.Semenova, I.Kozlovskiĭ, N.Zakharova, M.Kozlovskaia, Comparison of the effects of Selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA. 2009;72(4):6-8.
- No authors listed, Compensatory and antiamnestic effects of heptapeptide Selank in monkeys. 2008;44(3):284-90.
- T.Kolomin, T.Agapova, V. Agniullin, S.Shram, M.Shadrina, P.Slominskiĭ, S. Limborskaia, I.Miasoedov, Transcriptome alteration in the hippocampus under the treatment of tuftsin analog Selank. 2013;63(3):365-74. DOI: 10.7868/s0044467713030052
- F.Ershov, P.Uchakin, O.Uchakina, M.Mezentseva, L.Alekseeva, N.Miasoedov, Antiviral activity of immunomodulator Selank in experimental influenza infection. 2009;54(5):19-24.
- L.Inozemtseva, E. Karpenko, O.Dolotov, N.Levitskaya, A.Kamensky, L. Andreeva, I.Grivennikov, Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. 2008 421:241-3. doi: 10.1134/s0012496608040066.




