English
SELANK SHOWS NEUROREGULATORY AND ANTI-STRESS EFFECTS DUE TO:
- Modulation of the serotonergic and dopaminergic systems – restores emotional balance, reduces tension and anxiety.
- Increase in BDNF expression – supports neuroplasticity and neuron regeneration.
- Effect on GABA – naturally calms without sedation or dullness.
- Improvement of sleep quality and concentration – stabilizes the circadian rhythm and facilitates mental recovery.
- Immunomodulatory action – strengthens the immune response and limits inflammation.
💡 Effect: calmness, clear thinking, better sleep, and mental resilience to everyday stress.
STRUCTURE OF THE SELANK PEPTIDE
- Amino acid sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Empirical formula: C₃₃H₅₇N₁₁O₉
- Molecular weight: 751.89 g/mol
- Form: white lyophilizate, well soluble in water, stable over a wide pH range
RESEARCH AND BIOLOGICAL ACTIVITY
SELANK and the nervous system and mood
SELANK modulates the activity of the dopaminergic and serotonergic systems, stabilizing mood and reducing hyperactivity.
Clinical studies have shown that it reduces anxiety symptoms and emotional tension, while improving concentration and working memory.
SELANK and sleep and recovery
The peptide regulates the circadian rhythm by influencing the synthesis of serotonin and melatonin.
It facilitates falling asleep, deepens the deep sleep phase, and improves body recovery. Thanks to its calming effect, it does not cause daytime drowsiness or dependence.
Figure 1. Influence of the Selank peptide on BDNF levels in the hippocampus of the tested subject, 3 and 24 hours after peptide administration at doses of 250 and 500 μg/kg body weight. The study used the following labels: 1 – control, 2 – Selank at 250 μg/kg, 3 – Selank at 500 μg/kg. Selank significantly increased BDNF mRNA concentration in the hippocampus by a factor of 1.5-2 compared to control, 3 hours after administration at doses of 250 or 500 μg/kg body weight. The result clearly shows a statistically significant 30% increase compared to control BDNF levels in the rat hippocampus 24 hours after peptide administration at doses of 250 or 500 μg/kg body weight, proving its positive effect on maintaining and restoring proper cognitive functions of the body.
SELANK and oxidative stress and immunity
SELANK reduces levels of pro-inflammatory cytokines (including IL-6), which lowers oxidative stress and supports the immune system.
In in vivo models, its anti-inflammatory and immunomodulatory effects have been confirmed – it increases resistance to infections and improves the body's balance.
SELANK and cognitive functions
By affecting neurotransmitters and neurotrophic factors, SELANK supports memory, reaction speed, and mental clarity.
Studies observed improved results in cognitive tests and better information processing under stress.
| Property | Biological effect |
|---|---|
| Modulation of serotonin and dopamine | Reduction of stress and emotional tension |
| Increase in BDNF | Neuron regeneration and mood improvement |
| Regulation of circadian rhythm | Better sleep and concentration |
| Effect on GABA | Natural calming without sedation |
| Immunomodulatory action | Strengthening immunity and body balance |
Bibliography
- T.Semenova, I.Kozlovskiĭ, N.Zakharova, M.Kozlovskaia, Comparison of the effects of Selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA. 2009;72(4):6-8.
- No authors listed, Compensatory and antiamnestic effects of heptapeptide Selank in monkeys. 2008;44(3):284-90.
- T.Kolomin, T.Agapova, V. Agniullin, S.Shram, M.Shadrina, P.Slominskiĭ, S. Limborskaia, I.Miasoedov, Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank. 2013;63(3):365-74. DOI: 10.7868/s0044467713030052
- F.Ershov, P.Uchakin, O.Uchakina, M.Mezentseva, L.Alekseeva, N.Miasoedov, Antiviral activity of immunomodulator Selank in experimental influenza infection. 2009;54(5):19-24.
- L.Inozemtseva, E. Karpenko, O.Dolotov, N.Levitskaya, A.Kamensky, L. Andreeva, I.Grivennikov, Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. 2008 421:241-3. doi: 10.1134/s0012496608040066.