BPC-157 5MG
129.00zł
- Product Application: THIS PRODUCT IS INTENDED AND LABELED SOLELY AS A RESEARCH REAGENT. This designation allows the use of research chemicals exclusively for in vitro research and laboratory experiments. All product information available on this site is for educational purposes only. Introducing the product into the bodies of humans or animals is strictly prohibited by law. This product should only be handled by licensed, qualified professionals. The product is not a drug, food, or cosmetic and must not be mislabeled, labeled as a drug, food, or cosmetic, or improperly used.
What is BPC-157?
BPC stands for Body Protective Compound, which means, literally translated, Body Protective Compound, and that is precisely the function of this peptide. In conducted laboratory studies, the peptide has proven effective mainly in musculoskeletal injuries and gastrointestinal ailments.
BPC naturally occurs in the human body, specifically in the gastrointestinal tract. Fragment 157 is a 15-amino acid fragment of BPC and is the most characterized, studied, and essential part for BPC activity, forming the BPC-157 peptide.
BPC-157 exhibits protective and regenerative effects due to:
- Promoting new blood vessel growth: BPC-157 stimulates the production of vascular endothelial growth factor (VEGF), which supports the formation of new blood vessels. This allows for improved blood flow to damaged tissues, accelerating the healing process.
- Reducing inflammation: BPC-157 can inhibit the production of pro-inflammatory cytokines and promote the production of anti-inflammatory cytokines. This action helps to reduce inflammation.
- Protecting against cell death: BPC-157 can protect cells from damage caused by oxidative stress, free radicals, and other harmful factors. This can help promote cell survival and healing.
- Stimulating tissue repair: BPC-157 supports the stimulation of collagen production and other proteins essential for tissue repair.
Structure of BPC-157 Peptide
Source: Chemical Book
Sequence: GLY–GLU–PRO–PRO–PRO–GLY–LYS–PRO–ALA–ASP–ASP–ALA–GLY–LEU–VAL
Molecular Formula: C62 H98 N16 O22
Molecular Weight: 1419.56 g/mol
Research on BPC-157 Peptide
a) BPC-157 and Wound Healing
BPC-157 has the ability to accelerate the formation of new tissues and enhance collagenase, leading to faster healing of wounds, cuts, or burns. The peptide promotes the action of vascular endothelial growth factor (VEGF), causing the formation of new blood vessels that support skin regeneration processes. Cell proliferation is also accelerated, making wound healing faster and more effective, and resulting scars smaller and less pronounced.
Any skin injury results in a recovery period and, later, scar formation. BPC-157 not only helps alleviate symptoms and accelerate recovery but also minimizes the scarring resulting from the injury.
b) BPC-157 and Tendon Damage Healing
BPC-157, by promoting angiogenesis, leads to the formation of new blood vessels, delivering adequate amounts of blood and nutrients needed for faster tendon regeneration.
Additionally, BPC-157 has the ability to activate fibroblasts, which are responsible for repairing and maintaining tissues, leading to faster healing of damaged tendons. Increased activity and the number of fibroblasts are essential during tendon healing, as blood supply to these tissues is poor, limiting tendon repair.
Source: PubMed
c) BPC-157 and Musculoskeletal System Regeneration
Laboratory studies have noted that postoperative therapy with BPC-157 peptide yields satisfactory results and can lead to faster recovery of physical fitness, reduced pain, and shortened recovery time due to its regenerative abilities. BPC-157 peptide alleviated the effects of interventions on bone structure and soft tissues.
Source: PubMed
d) BPC-157 and Gastrointestinal System Regeneration
The cytoprotective effect of BPC-157 may indicate that it becomes a new mediator in the cytoprotective response, both adaptive and protective, acting against exogenous and endogenous irritants. BPC-157 is stable in gastric juice and, combining regenerative processes, shows a wide range of healing effects from NSAID (non-steroidal anti-inflammatory drugs) therapy.
The angiogenesis induced by BPC-157 creates new blood vessels from existing ones. This process allows BPC-157 peptide to be used in the healing of gastric ulcers and liver damage caused by NSAID therapy.
Source: PubMed
Figure 3. Presentation of changes in the liver caused by celecoxib, an NSAID (A), and after administration of BPC-157 peptide (a). Administration of BPC-157 minimizes the harmful effects of NSAIDs on the liver.
BPC-157 significantly alleviated liver damage caused by celecoxib. Before using BPC-157, there was marked microvesicular and macrovesicular steatosis, expanded sinusoids, and patchy liver necrosis.
e) BPC-157 and Hypertension Reduction
BPC-157 peptide has properties that influence the process of vasodilation, or the widening of blood vessels, leading to a decrease in blood pressure. The mechanism of action of BPC-157 peptide allows for its protective effect, preventing blood pressure increases safely and without side effects.
In the conducted study, BPC-157 peptide, depending on the concentration used, caused vasodilation in aortic rings with an intact endothelium. Vasodilation at BPC-157 concentrations of 0.1 or 1 μg/mL ranged from 16.5±5.5% to 19.5±3.0%, at a concentration of 10 μg/mL 28.3±3.5%, and at a dose of BPC-157 of 100 μg/mL 48.3±3.2%. Additionally, vasodilation in this study due to BPC-157 was persistent, maintained continuously, and quickly achieved.
f) BPC-157 and the Urogenital System
Due to its action profile, BPC-157 peptide causes tissue flexibility, leading to strengthening of the pelvic floor muscles. Other articles mention that the peptide also affects the nervous system, which, in cases of urinary incontinence, results in stopping the feeling of bladder urgency. The action of BPC-157 peptide allows for the thickening of the urethral muscle structure, significantly reducing the risk of urinary incontinence in the future.
A laboratory study showed that BPC-157 peptide therapy, regardless of the dosing regimen or administration method, completely counteracts the decrease in LPP (leak point pressure), or the level of intravesical pressure. BPC-157 achieved baseline values noted in healthy study subjects. Additionally, the urethral wall treated with BPC-157 showed a thicker and more regular muscle structure compared to the control group, which had a thin muscle layer.
Bibliography
- L.He, D.Feng, H.Guo, Y.Zhou, Z.Li, K.Zhang, W.Zhang, S.Wang, Z.Wang, Q.Hao, C.Zhang, Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. 2022; 13: 1026182. 10.3389/fphar.2022.1026182
- S.Seiwerth, M.Milavic, J.Vukojevic, S.Gojkovic, I.Krezic, L.Batelja-Vuletic, K.Pavlov, A.Petrovic, S. Sikiric, H.Vranes, A.Blagaic, P.Sikiric, Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. 2021; 12: 627533. 10.3389/fphar.2021.627533
- D.Perovic, D.Kolenc, V.Bilic, N.Somun, D.Drmic, E.Elabjer, G.Buljat, S.Seiwerth, P.Sikiric, Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. 2019; 14: 199. 10.1186/s13018-019-1242-6
- M.Staresinic, MJapjec, H.Vranes, A.Prtoric, H.Zizek, Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle. 2022; 10(12): 3221. 10.3390/biomedicines10123221
- S.Strbe, S.Gojkovic, I.Krezic, H.Zizek, H.Vranes,I.Barisic, D.Strinic, Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157. 2021 Nov; 9(11): 1506. 10.3390/biomedicines9111506
- C.Chang, W.Tsai, M.Lin, Y.Hsu, J.Pang, The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. 201; 110(3):774-80. doi:10.1152/japplphysiol.00945.2010.
