3PAK GHK-Cu 20MG
Original price was: 387.00zł.290.25złCurrent price is: 290.25zł.
- Product Application: THIS PRODUCT IS INTENDED AND LABELED SOLELY AS A RESEARCH REAGENT. This designation allows the use of research chemicals exclusively for in vitro research and laboratory experiments. All product information available on this site is for educational purposes only. Introducing the product into the bodies of humans or animals is strictly prohibited by law. This product should only be handled by licensed, qualified professionals. The product is not a drug, food, or cosmetic and must not be mislabeled, labeled as a drug, food, or cosmetic, or improperly used.
What is GHK-Cu?
GHK, which occurs naturally in the human body, combined with copper, significantly accelerates wound healing and skin repair. The level of the GHK peptide decreases with age, resulting in a noticeable decline in the body’s regenerative abilities.
In the research conducted so far, it has been observed that the GHK-Cu copper complex significantly accelerates wound healing and contraction, improves the condition of the skin, especially damaged, compromised, or aged skin, and has anti-inflammatory and antioxidant effects.
GHK-Cu supports skin repair processes due to:
- Reducing activity: GHK-Cu peptide, as a metalloproteinase inhibitor, has the ability to tighten loose skin, improve its elasticity, density, and firmness, and reduce the formation of photodamage and discoloration on its surface.
- Participating in the process of rebuilding the skin’s hydrolipid barrier: GHK-Cu can increase the concentration of lipids and ceramides in the skin, improving its elasticity and thickness. Additionally, due to the presence of copper in the peptide, its penetration ability in the body is increased, which can double its effectiveness.
- Stimulating collagen synthesis: Stimulating selected compounds (glycosaminoglycans), whose presence ensures proper water retention in the skin, improves the skin’s hydration and moisture.
- Accelerating the distribution of keratinocytes: Keratinocytes, responsible for producing keratin in the skin, strengthen the skin and ensure proper collagen synthesis, improving the skin’s thickness, elasticity, and firmness, which also reduces wrinkles and mitigates photodamage effects.
Structure of the GHK-Cu peptide
Source: MedChem
Sequence: GLY–HIS–LYS (Cu2+)
Molecular Formula: C14 H23 Cu N6 O4
Molecular Weight: 340.384 g/mol
Research on the GHK-Cu peptide
a) GHK-Cu and its anti-aging function
The GHK-Cu peptide accelerates the distribution of keratinocytes (responsible for producing keratin in the skin, strengthening it) and proper collagen synthesis, improving the skin’s thickness, elasticity, and firmness, additionally reducing wrinkles and mitigating photodamage effects. GHK-Cu stimulates active, multi-faceted remodeling of the skin’s extracellular matrix (the substance filling the space between skin cells, consisting of collagen and elastin fibers, glycoproteins, and glycosaminoglycans – primarily hyaluronic acid) and subcutaneous tissue, increasing its elasticity and stability with a visible improvement in its resilience.
Source: PubMed
Figure 1. In a cell culture, the tissue was treated with: a) GHK-Cu preparation and exposed to UV light (Tissue-PC), b) UV light exposure (Tissue-NC), and c) Negative control (no GHK-Cu preparation or UV light exposure).
As shown, the tissue treated with GHK-Cu had the highest fluorescence intensity (green line) and the greatest reduction in cell nuclei (blue, round points). The intensity of green fluorescence quantitatively reflects collagen concentration, thus proving the positive effect of the GHK-Cu peptide on skin repair and regeneration.
b) GHK-Cu and respiratory improvement
In a laboratory test, it was shown that therapy with the GHK-Cu peptide reduced the production of reactive oxygen species (ROS) in the study subjects and increased superoxide dismutase (SOD) activity while reducing TNF-α and IL-6 production by suppressing NF-κB p65 and p38 MAPK signaling. This way, the peptide mitigated lung histological changes caused by damage and suppressed inflammatory cell infiltration into lung parenchyma, alleviating lung damage and eliminating inflammation. Additionally, the GHK-Cu peptide used in the study supported regenerative processes after pneumonia.
c) GHK-Cu and its analgesic and anti-inflammatory effects
A laboratory study showed that the GHK-Cu peptide has analgesic and anti-inflammatory properties. The L-lysine component of the peptide plays a particular role in its analgesic process. The peptide regulates and triggers the action of peptidases and the creation of tissue-specific processing products. It was also proven that the action of GHK-Cu reduces serotonin secretion responsible for the development of neurogenic inflammation at the injury site, manifesting as pain symptoms.
During the study of the anti-inflammatory potential of the GHK-Cu peptide, it was shown to help inhibit inflammatory and fibrotic changes, alleviate the inflammatory response by reducing the levels of pro-inflammatory cytokines TNF-ɑ and IL-6, and MPO activity (myeloperoxidase concentration). Additionally, the action of GHK-Cu significantly reverses the MMP-9/TIMP-1 imbalance and partially prevents EMT (epithelial-mesenchymal transition) through Nrf2, NF-κB, and TGFβ1 pathways and Smad2/3 phosphorylation.
d) GHK-Cu and cardiotoxicity
Bibliography
- L.Pickart, A.Margolina, Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. 2018; 19(7): 1987. 10.3390/ijms19071987
- F.Jiang, Y.Wu, Z.Liu, M.Hong, Y.Huang, Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests. 2023; 22(9):2598-2604. doi: 10.1111/jocd.15763
- L.Pickart, A.Margolina, Regenerative and Protective Actions of the GHK-Cu. 2018; 19; doi:10.3390/ijms19071987
- Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016;7(36):58405-58417. doi:10.18632/oncotarget
- W Ma, M Li, H Ma, W Li, L Liu, Y Yin, X Zhou, G Hou.Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways 2019. 10.1016/j.lfs.2019.117139
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. Published 2018 Jul 7. doi:10.3390/ijms19071987
