3PAK EPITHALON 10MG
387.00zł
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What is Epithalon?
Epithalon peptide is derived from epithalamin, a naturally occurring polypeptide in the human body produced by the pineal gland.
The primary function of the Epithalon peptide is to significantly delay and inhibit the development of changes in the body associated with aging.
Laboratory studies indicate that in addition to its anti-aging properties, Epithalon peptide has the ability to regulate the circadian rhythm, promote deeper sleep, improve vision, and exhibit strong antioxidant activity.
Epithalon exhibits anti-aging effects on the body due to:
- Impact on telomerase: Epithalon has properties that inhibit the process of telomere shortening, which causes aging. The faster the telomere shortens, the quicker aging processes occur. Telomeres shorten with each cell division, so it can be said that the shortening telomere acts as a “counter,” as the increasing number of cell divisions with age deepens the aging process and increases the risk of age-related diseases.
- Impact on gene expression: Epithalon positively influences changes in gene expression that can lead to disruptions in the production of specific regulatory peptides, which in turn cause adverse, pathological changes in tissues and organs.
- Impact on antioxidation: The balance between harmful oxidants, such as free radicals, and antioxidants, which neutralize them, should be maintained. If this balance is disrupted, oxidative stress occurs in the body, which is a cause of accelerated aging and the development of many age-related diseases. Epithalon peptide promotes processes that neutralize the formation of free radicals, in other words, the peptide restores the disrupted balance in the body, inhibiting aging processes.
Structure of the Epithalon Peptide
Source: MedChem
Sequence: ALA–GLU–ASP–GLY
Molecular formula: C14 H22 N4 O9
Molecular weight: 390,35 g/mol
Studies on the Epithalon Peptide
a) Epithalon and Prevention of Aging
Many studies have been conducted using telomerase-negative fibroblast cultures as aging cells. The action of the Epithalon peptide resulted in the induction of the expression of the catalytic subunit, enzymatic activity of telomerase, and the elongation of telomeres, most likely due to the reactivation of the telomerase gene in somatic cells. This suggests the possibility of extending the lifespan of cell populations and the entire organism through the use of the peptide.
Other earlier studies conducted on animal models showed that the use of Epithalon reduced the frequency of chromosomal mutations, which was also consistent with the elongation of telomeres and thus slowing down the aging process. A study using oocytes also confirmed the anti-aging potential of the Epithalon peptide.
Source: PubMed
Figure 1. In this study conducted on animal oocytes, the effect of Epithalon on stopping cell aging was observed. The image in the control group shows oocyte cells, the next image shows aging cells, and the image labeled “Epithalon” shows the halt in cell aging. The cells in the image, under the influence of the Epithalon peptide, are in the same quantity, and any damage has been minimized, proving the anti-aging potential of the peptide.
b) Epithalon and Facilitating Sleep
Epithalon is used to increase the natural production of telomerase, an enzyme that helps cells regenerate telomeres, the protective parts of DNA. Ultimately, this leads to a slowing down of the aging of cell populations. Studies have also shown that Epithalon helps restore and normalize the production of melatonin by the pineal gland and restores the normal circadian rhythm of cortisol production, ensuring better sleep at night.
As the body ages, there is a decreased nocturnal circadian level of melatonin in blood plasma and a decreased amplitude of the hormonal circadian rhythm, indicating disturbances in the pineal gland’s melatonin release function. The peptide preparation Epithalon restores the nocturnal secretion of endogenous melatonin and leads to the normalization of the hormonal circadian rhythm in blood plasma. Experiments clearly show that Epithalon increased evening melatonin levels. The melatonin content in subjects treated with Epithalon was over three times higher than in the control group. Epithalon not only stimulated melatonin synthesis but also normalized the circadian rhythms of cortisol levels in peripheral blood.
c) Epithalon and Vision Improvement
According to studies, Epithalon prolongs the functional integrity of the retina with hereditary retinal pigment inflammation by enhancing the bioelectrical and functional activity of the retina while maintaining its morphological structure. The clinical effect is visible in 90% of cases. The analysis of Epithalon’s action suggests that the tetrapeptide participates in transcription mechanisms common to the pineal gland and retina, thus improving vision.
d) Epithalon and Blood Pressure Reduction
Hypertension is often accompanied by lipid disorders, such as hypercholesterolemia, and most commonly atherogenic dyslipidemia, characterized by increased triglycerides and decreased HDL cholesterol. A study showed that individuals administered the Epithalon peptide had improved and, most importantly, normalized lipid metabolism, leading to a reduction in hypertension and decreasing the overall risk of cardiovascular diseases.
e) Epithalon and Stress Elimination
Studies on the Epithalon peptide have shown that it increases the proliferative activity of thymocytes, both enhanced by rotational stress and suppressed by combined stress. The peptide also enhanced the coexisting effect of IL-1beta. The study results corresponded to the influence of Epithalon on various stress-induced changes in nSMase activity in the P2 fraction of the cerebral cortex. Epithalon-activated nSMase in cortical membranes increased the stimulating effect of IL-1beta on enzyme activity. This study confirms that the Epithalon peptide exhibits protective anti-stress effects at the level of IL-1beta signal transmission via the sphingomyelin pathway in neural tissue and at the level of target thymocyte proliferation.
Bibliography
- V.Kh Khavinson, Peptides and Ageing. 2002; 3:11-144
- V.Khavinson, M.Razumovsky, S.Trofimova, R.Grigorian, A.Razumovskaya, Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa, 2002; 365-8
- Apostolopoulos V, Bojarska J, Chai TT, et al. A Global Review on Short Peptides: 2.Frontiers and Perspectives. Molecules. 2021;26(2):430. Published 2021 Jan 15. doi:10.3390/molecules26020430
- Adult Treatment Panel III.: Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel of detection, evaluation and treatment of high blood cholesterol in adults. JAMA 2001, 285: 2486-97
- D.Sibarov, R.Kovalenko, V.Malinin, V.Khavinson, Epitalon influences pineal secretion in stress-exposed rats in the daytime. 2002; 23(5-6):452-4
- L.Kozina, Investigation of antihypoxic properties of short peptides. 2008;21(1):61-7
- V.Khavinson, E.Korneva, V.Malinin, E.Rybakina, I.Ivanovich, S,Shanin, Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress. 2002; 23(5-6):411-6
- X.Yue, S.Liu, J.Guo, T.Meng, X.Zhang, H.Li, C.Song, Z.Wang, H.Schatten, Epitalon protects against postovulatory aging-related damage of mouse oocytes in vitro. 2022 Apr 15; 14(7): 3191–3202.10.18632/aging.204007
