3PAK CORTAGEN 10MG
387.00zł
The Cortagen peptide has the ability to regulate and restore ATP levels in neurons, as well as to prevent excessive activation of lipid peroxidation and a decline in antioxidant activity in brain tissues. This not only makes it a neuroprotective preparation but also a remedy for alleviating the effects of brain damage caused by past diseases, addictions affecting brain function, or microtraumas (which may occur, for example, in athletes involved in disciplines that include impacts or collisions, as well as in individuals performing jobs associated with such events).
- Product Application: THIS PRODUCT IS INTENDED AND LABELED SOLELY AS A RESEARCH REAGENT. This designation allows the use of research chemicals exclusively for in vitro research and laboratory experiments. All product information available on this site is for educational purposes only. Introducing the product into the bodies of humans or animals is strictly prohibited by law. This product should only be handled by licensed, qualified professionals. The product is not a drug, food, or cosmetic and must not be mislabeled, labeled as a drug, food, or cosmetic, or improperly used.
What is Cortagen?
peptide is employed to activate brain repair processes and enhance brain activity, supporting the treatment and prevention of neurodegenerative brain diseases.
Cortagen exhibits strong bioregulatory properties, particularly in the area of the central nervous system.
Cortagen supports brain function and repair processes due to:
- Impact on translational and transcriptional mechanisms: Cortagen influences the expression of genes encoding structural and enzymatic proteins, regulating repair processes in neurons and the synthesis of proteins necessary for the proper functioning of nerve cells, such as heat shock proteins (HSP).
- Elimination of harmful free radicals: Acting as a free radical scavenger, Cortagen protects lipids, proteins, and DNA in neurons from oxidative damage.
- Prevention of cell apoptosis: By acting as a caspase inhibitor, Cortagen reduces their activity, preventing apoptosis and protecting nervous system cells. Additionally, Cortagen regulates the level of Bcl-2 protein, providing dual anti-apoptotic capabilities.
- Ability to stimulate neurogenesis: Neurogenesis, the process of forming new neurons, is supported by Cortagen’s action. Brain damage repair is facilitated by the growth of progenitor cells and synaptic growth promoted by Cortagen.
Structure of the Cortagen Peptide
Source: BiolChem
Sequence: Ala-Glu-Asp-Pro
Molecular Formula: C17 H27 N5 O8
Molecular Weight: 430.17 g/mol
Research on Cortagen
a) Cortagen and Improved Well-being
Laboratory studies examining the relationship between Cortagen’s effects and its properties for enhancing well-being demonstrated that a specific dose of the peptide increased locomotion during both acute and chronic treatment of anxiety-related conditions. Cortagen stimulates motor activity without side effects on emotional or affective profiles. This behavioral stimulation could be beneficial in treating affective/depressive symptoms. Cortagen is effective even in very low doses without side effects, and further research could yield more positive results and benefits.
b) Cortagen and Nervous Tissue Regeneration and Anti-Aging
The peptide bioregulator Cortagen demonstrated a clear therapeutic effect on the structural and functional regeneration of damaged peripheral nervous tissue. Studies on the bioregulation of synthetic Cortagen peptide showed its impact on total constitutive heterochromatin and facultative heterochromatin (transcriptionally inactive euchromatin). Molecular cytogenetic methods revealed variability in facultative heterochromatin (FH) in cultured lymphocytes of tested individuals. Cortagen induced deheterochromatinization (decondensation) of total heterochromatin, activated synthetic processes of ribosomal genes via deheterochromatinization of acrocentric chromosome satellite stalks, did not induce deheterochromatinization of pericentromeric structural heterochromatin, and released repressed genes caused by condensation of euchromatic regions forming FH. These findings suggest that Cortagen protects and regenerates nervous tissue while preventing its aging.
c) Cortagen a ochrona mięśnia sercowego
c) Cortagen and Cardiomyocyte Protection
Laboratory studies focusing on Cortagen’s role proved its positive effects on cardiac muscle protection. Among other actions, the peptide increased the expression of the heat shock protein Hsc70, crucial for protecting cardiac muscle, regulated the expression of Bmp2 and Wnt4 genes involved in programmed cell death and heart tissue formation, and enhanced cardiac expression of both the subtype 15 epidermal growth factor receptor (Eps15) and its associated sequence (Eps15-rs), which regulate mitogenic signals, normal, and cancerous proliferation.
Figure 1. The figure illustrates changes in gene expression caused by Cortagen (Dst, dystonin; Ampd3, AMP deaminase type H) compared to controls, proving its potential protective effect on the cardiac muscle.
Bibliography
- W.Adriani , O.Granstrem , E.Romano , O.Granstrem , S.Koroleva, G.Laviola, Modulatory Effects of Cortexin and Cortagen on Locomotor Activity and Anxiety-Related Behavior in Mice. The Open Neuropsychopharmacology Journal; 2011, 2: 22-29. doi: 10.2174/1876523800902010022
- T.Fedorova, N.Boldyrev, A.Khavinson, Neuroprotective properties of the synthetic peptide Cortagen. Bulletin of Experimental Biology and Medicine. 2001. DOI: 10.1023/A:1014445014563
- V.Khavinson, E.Grigoriev, I.Ryzhak, Effects of the peptide Cortagen on the regeneration of nerve tissue. Neuroscience and Behavioral Physiology. 2003. DOI: 10.1023/A:1024404701418
- V.Khavinson, I.Ryzhak, E.Grigoriev, Cortagen effects on memory and learning in neurodegenerative disorders. Journal of Peptide Science. 2011. DOI: 10.1002/psc.1362
- V.Sergey, V.Khavinson, V.Anisimov, Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray. 2004; NeuroendocrinologyLetters
