The main concern with the use of BPC-157 peptide in its primary form was the degree of its release and absorption from the gastrointestinal tract and the effect of temperature on its activity. Due to the high concentration of H+ ions in the lumen of the stomach, the gastric juice produced there affects the bioavailability of the substance by reducing the absorption of the component. Gastric juice is strongly acidic, its pH value in a healthy person is 1.2 ± 0.3. It is a mixture of water, hydrochloric acid, sodium and potassium chloride, phosphates, sulfates, pepsin, a small amount of lipase, renin and mucus. During the activation of one of the components, which is pepsin, which is a phophoprotein, a peptide is cut off, which inhibits its activation with hydrochloric acid through autocatalysis. This process leads to rapid degradation and reduced stability of the enzyme. The BPC-157 peptide in its basic form does not have the ability to pass through the body's gastric barrier. Its activity, stability and absorbability in this form are at levels that prevent it from entering the central bloodstream. This leads to failure to achieve the expected therapeutic effect. The peptide in its basic form must additionally be released through a complex organic matrix, which is impossible in unmodified form.
BPC-157 is the term for pentadecapeptide, a protein with 15 amino acids. According to the patent, BPC-157 refers to "peptides containing 8-15 amino acid residues with a molecular weight of 900-1600 daltons." Its structure is shown as a formula: [Zaa Pro Pro Pro Xaa Yaa Pro Ala](-) or (2-) The BPC-157 peptide is widely used in the supplementation of professional athletes as well as physically active individuals. To date, it has been found in the environment in the form of subcutaneous, injectable delivery. Attempts to administer the peptide in oral form have posed problems related to the preservation of its biological activity in the body.
A typical peptide is a compound made of amino acids, where a peptide bond is formed between the amino group (-NH2) of one amino acid and the carboxyl group (-COOH) of the other amino acid. Through synthetic modifications, the BPC-157 peptide has been reduced to a form of the NL-BPC-157 TM analog, which is a compound with high application potential, making it possible to administer it via the per os (oral) route.
BPC-157 has long helped physically active people and professional athletes in recovery processes. Showing a broad spectrum of action, it can be said to target a larger audience than the aforementioned.
One example is the effect of BPC-157 on the digestive system. In cases of convalescence, after surgical procedures, especially in the case of the gastric mucosa where regeneration is needed, which is essential for the normal functioning of the body.
It helps stabilize blood pressure, through the production of nitric oxide, and during hyperkalemic disorders caused by too high a concentration of lithium in the body.
In addition, it influences the activity of neurotransmitters such as serotonin and dopamine, so it can show supportive effects in the treatment of depressive conditions or pain complaints.
The results of the study also indicate the ability of BPC-157 to reverse the toxic effects of drugs from the group of non-steroidal anti-inflammatory drugs (NSAIDs) .
Epithalon is the term for a tetrapeptide of amino acids with the sequence Ala - Glu - Asp - Gly, having a molecular weight of 390.35 g/mol. Epithalon peptide is widely used in rejuvenation and regeneration therapies.
Epithalon is derived from Epithalamin (Epithalamine), a naturally occurring polypeptide that is produced in the pineal gland. So far, it has been found in the environment in the form of subcutaneous, injectable delivery. Attempts to administer the peptide in oral form have posed problems related to the preservation of its biological activity in the body.
A typical peptide is a compound made of amino acids, where a peptide bond is formed between the amino group (-NH2) of one amino acid and the carboxyl group (-COOH) of the other amino acid. Through synthetic modifications, the Epithalon peptide has been reduced to the form of the NL-EPITHALON TM analog, which is a compound with high application potential, making it possible to administer it via the per os (oral) route.
GHK-CU is the term for an amino acid tripeptide with a glycyl-L-histidyl-L-lysine sequence, having a molecular weight of 403.9242 g/mol. GHK-CU is widely used in cosmetology for its protective and regenerative properties.
So far, it has been found in the environment in the form of subcutaneous, injectable delivery. Attempts to administer the peptide in oral form have posed problems related to the preservation of its biological activity in the body.
A typical peptide is a compound made of amino acids, where a peptide bond is formed between the amino group (-NH2) of one amino acid and the carboxyl group (-COOH) of the other amino acid. Through synthetic modifications, the GHK-CU peptide has been reduced to the form of the NL-GHK-CU TM analog, which is a compound with high application potential, making it possible to administer it via the per os (oral) route.
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