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WHAT IS BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide, a fragment of a natural protein found in human gastric juice.
Its unique 15-amino acid structure has been designed to maintain stability and biological activity under the harsh conditions of the gastric environment.
BPC-157 shows high effectiveness in regenerative processes, supporting the reconstruction of soft tissues, tendons, muscles, and bones. Laboratory studies have confirmed its impact on angiogenesis, collagen synthesis, and regulation of the body's inflammatory response.
BPC-157 SHOWS PROTECTIVE AND REGENERATIVE ACTION THANKS TO:
- Stimulation of angiogenesis – stimulates the production of vascular endothelial growth factor (VEGF), improving microcirculation and accelerating the repair of damaged tissues.
- Increased collagen synthesis – supports regenerative processes of skin, tendons, and mucous membranes.
- Anti-inflammatory action – reduces oxidative stress and modulates the activity of pro-inflammatory cytokines (TNF-α, IL-6).
- Protection of vascular endothelium – stabilizes cell membranes and limits capillary degradation.
- Regulation of cellular homeostasis – supports the balance between cell proliferation and apoptosis, accelerating the regeneration process.
💡Effect: faster wound healing, regeneration after injuries and procedures, and improvement of gastrointestinal and musculoskeletal organ functions.
BPC-157 PEPTIDE STRUCTURE
- Amino acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Empirical formula: C₆₂H₉₈N₁₆O₂₂
- Molecular weight: 1419.56 g/mol
- Form: lyophilizate (white / creamy), soluble in demineralized water
RESEARCH AND BIOLOGICAL ACTIVITY
BPC-157 and the wound healing process
BPC-157 demonstrates the ability to rapidly form new tissues and stimulate collagen.
Supports angiogenesis by increasing VEGF expression, which improves blood supply and nutrient transport.
In in vivo models, a clear shortening of the healing time of wounds, burns, and skin injuries is observed.
BPC-157 and tendon and muscle regeneration
The compound stimulates the activity of fibroblasts responsible for collagen production and connective tissue remodeling.
Studies have shown that BPC-157 increases blood flow at the injury site and improves the elasticity and mechanical resistance of tendons.
Figure 1. The study was conducted under laboratory conditions for 7 days. The study compared damaged tendon cells in the control group untreated with any preparation to the test group (BPC-157 at concentrations of 1 ug/ml and 2 ug/ml). The conclusions clearly show an increased number of fibroblasts in the group treated with the BPC-157 peptide at both concentrations, proving the positive effect of the peptide on damaged tendons.
BPC-157 and the digestive system
The compound shows strong cytoprotective effects on the mucous membranes of the stomach and intestines.
It accelerates the regeneration of damaged epithelium, reduces inflammation, and limits hydrochloric acid secretion.
BPC-157 and the skeletal system
The peptide supports osteogenesis by stimulating osteoblast activity and increasing type I collagen synthesis.
In fracture models, shortening of bone healing time and improvement of their mechanical strength were observed.
| Property | Biological effect |
|---|---|
| Stimulation of angiogenesis (VEGF) | Accelerated wound healing, improved blood supply and nourishment of tissues |
| Increased collagen synthesis | Regeneration of skin, tendons, muscles, and mucous membranes |
| Activation of fibroblasts and osteoblasts | Faster rebuilding of connective and bone tissues |
| Anti-inflammatory action | Reduction of pro-inflammatory cytokines (TNF-α, IL-6) and oxidative stress |
| Protection of the vascular endothelium | Stabilization of capillaries, improvement of microcirculation |
| Regulation of cellular homeostasis | Support for the balance between cell proliferation and regeneration |
| Cytoprotective effect on the digestive system | Regeneration of the stomach and intestinal mucous membranes, protection against damage |
| Increased blood flow at the injury site | Improvement of oxygen and nutrient transport to tissues |
| Antioxidant action | Limiting free radicals and supporting natural defense mechanisms |
| Accelerating repair processes after injuries and surgeries | Shortening recovery time and more complete healing |
Bibliography
- L.He, D. Feng, H.Guo, Y.Zhou, Z. Li, K. Zhang, W. Zhang, S. Wang, Z. Wang, Q. Hao, C. Zhang, Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. 2022; 13: 1026182. 10.3389/fphar.2022.1026182
- S.Seiwerth, M. Milavic, J. Vukojevic, S. Gojkovic, I. Krezic, L. Batelja-Vuletic, K. Pavlov, A. Petrovic, S. Sikiric, H. Vranes, A. Blagaic, P.Sikiric, Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. 2021; 12: 627533. 10.3389/fphar.2021.627533
- D.Perovic, D. Kolenc, V. Bilic, N. Somun, D. Drmic, E. Elabjer, G. Buljat, S. Seiwerth, P. Sikiric, Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. 2019; 14: 199. 10.1186/s13018-019-1242-6
- M.Staresinic, M Japjec, H. Vranes, A. Prtoric, H. Zizek, Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle. 2022; 10(12): 3221. 10.3390/biomedicines10123221
- S.Strbe, S. Gojkovic, I. Krezic, H. Zizek, H. Vranes,I. Barisic, D. Strinic, Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157. 2021 Nov; 9(11): 1506. 10.3390/biomedicines9111506
- C.Chang, W. Tsai, M. Lin, Y. Hsu, J. Pang, The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. 201; 110(3):774-80. doi:10.1152/japplphysiol.00945.2010.